Dual Inhibition of Classical Protein Kinase C- and Protein Kinase C- Isoforms Protects Against Experimental Murine Diabetic Nephropathy
نویسندگان
چکیده
منابع مشابه
Dual Inhibition of Classical Protein Kinase C-α and Protein Kinase C-β Isoforms Protects Against Experimental Murine Diabetic Nephropathy
Activation of protein kinase C (PKC) has been implicated in the pathogenesis of diabetic nephropathy with proteinuria and peritubular extracellular matrix production. We have previously shown that the PKC isoforms α and β mediate different cellular effects. PKC-β contributes to hyperglycemia-induced renal matrix production, whereby PKC-α is involved in the development of albuminuria. We further...
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Chronic hyperglycemia is the main cause of diabetic microvascular complications of the kidney and retina. Multiple theories have been proposed to explain the adverse effects of hyperglycemia, including increased flux through the polyol pathway, excessive formation of advanced glycation end-products, oxidative stress, and altered signaling pathways such as protein kinase C (PKC). This article wi...
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Protein kinase C (PKC) isoforms have emerged as important regulators of cardiac contraction, hypertrophy, and signaling pathways that influence ischemic/reperfusion injury. This review focuses on newer concepts regarding PKC isoform-specific activation mechanisms and actions that have implications for the development of PKC-targeted therapeutics.
متن کاملInhibition of -Protein Kinase C Protects Against Reperfusion Injury of the Ischemic Heart In Vivo
Background—Current treatment for acute myocardial infarction (AMI) focuses on reestablishing blood flow (reperfusion). Paradoxically, reperfusion itself may cause additional injury to the heart. We previously found that -protein kinase C ( PKC) inhibition during simulated ischemia/reperfusion in isolated rat hearts is cardioprotective. We focus here on the role for PKC during reperfusion only, ...
متن کاملInhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo.
BACKGROUND Current treatment for acute myocardial infarction (AMI) focuses on reestablishing blood flow (reperfusion). Paradoxically, reperfusion itself may cause additional injury to the heart. We previously found that delta-protein kinase C (deltaPKC) inhibition during simulated ischemia/reperfusion in isolated rat hearts is cardioprotective. We focus here on the role for deltaPKC during repe...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2013
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db12-0534